Beggars banquet: Metabolism in the tumor immune ... - Cell Press
वेब29 जून, 2023 · Metabolism, the nervous system, and the immune system form a triumvirate of homeostasis. Recent research is exploring roles of this triumvirate in the TME. Neurotransmitters such as norepinephrine, aminobutyric acid (GABA), and acetylcholine have been studied in the context of tumor immunity and immunotherapy.
Issue: Cell Metabolism
वेब7 नोव्हें, 2023 · In mammal adolescence, cardiomyocytes rapidly exit the cell cycle, and heart regeneration in adults is limited after cardiac injury. Recent work by Li et al. in Nature revealed that inhibition of fatty acid oxidation can rewire cell metabolism and lead to epigenetic reprogramming of cardiomyocytes to an immature state that facilitates …
Impaired skeletal muscle regeneration in diabetes: From cellular …
वेब14 मार्च, 2024 · Diabetes represents a major public health concern with a considerable impact on human life and healthcare expenditures. It is now well established that diabetes is characterized by a severe skeletal muscle pathology that limits functional capacity and quality of life. Increasing evidence indicates that diabetes is also one of the most …
Glycine homeostasis requires reverse SHMT flux: Cell Metabolism
वेब2 जाने, 2024 · In metabolism, compartmentalization enables different reaction direction across organelles, cell types, or tissues. Glucose consumption by muscle glycolysis and production by hepatic gluconeogenesis is a classic example of opposite flux directions across tissues. Here, we show that the direction of SHMT flux is similarly tissue-dependent.
Apoptosis releases hydrogen sulfide to inhibit Th17 cell ...
वेब18 डिसें, 2023 · Moreover, apoptotic cells and vesicles (apoVs) express key H 2 S-generating enzymes and generate a significant amount of H 2 S, indicating that apoptotic metabolism is an important source of H 2 S. Mechanistically, H 2 S sulfhydrates selenoprotein F (Sep15) to promote signal transducer and activator of transcription 1 …
Deciphering the metabolic heterogeneity of hematopoietic stem cells …
वेब2 जाने, 2024 · The predicted metabolites covered glycolysis, citrate cycle, pentose phosphate pathway (PPP), pyruvate metabolism, amino acid biosynthesis, pyrimidine metabolism, etc. t-SNE visualization of metabolomics differences between stem and progenitor cell populations by SVM analysis showed that all hematopoietic cell …
Cell Metabolism | Vol 35, Issue 9, Pages 1491-1672 (5 September …
वेब5 सप्टें, 2023 · Read the latest articles of Cell Metabolism at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
UBE2M-mediated neddylation of TRIM21 regulates obesity ... - Cell …
वेब20 जून, 2023 · According to the manufacturer’s instructions, the real-time cell metabolism of PMs was measured using the Seahorse XF glycolytic stress test kit. PMs were seeded into XF 96-well plates at 50,000 cells per well and cultured overnight in a complete RPMI 1640 medium. The next day, PMs were washed and incubated for 1 h in Seahorse assay …
Supercharging cancer-fighting T cells with lithium carbonate - Cell …
वेब5 मार्च, 2024 · Lactate influences the behavior of various immune cell types. In a recent Nature Immunology study, Ma et al. revealed that lithium carbonate induces monocarboxylate transporter 1 translocation to mitochondria, enhancing cytoplasmic lactate transport into the mitochondria and increasing lactate mitochondrial metabolism, thereby …
Atlas of fetal metabolism during mid-to-late gestation and ... - Cell …
वेब8 डिसें, 2023 · Summary. Mounting evidence suggests metabolism instructs stem cell fate decisions. However, how fetal metabolism changes during development and how altered maternal metabolism shapes fetal metabolism remain unexplored. We present a descriptive atlas of in vivo fetal murine metabolism during mid-to-late gestation in normal …
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