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  1. Effect of Deficiency-adjusted Macronutrients to Cure Brown Bast ...

  2. Effect of Deficiency-adjusted Macronutrients to Cure Brown Bast ...

  3. Construction and analysis of the tapping panel dryness

  4. THE TORTURED POETS DEPARTMENT Lyrics and Tracklist - Genius

  5. Pertanika Journal

  6. Application of different rates and frequencies of rejuvenator for …

  7. لوگ بھی پوچھتے ہیں
    The design of bioTPD starts with identifying a binder with a good affinity for a desired target. Rapid and high-throughput techniques for screening extensive repertoires of high-specific binders are important tools for the development of bioTPD. The binders are commonly peptides, antibodies, and various antibody fragments.
    As an indispensable part of TPD, biological TPD (bioTPD) technologies including peptide-, fusion protein-, antibody-, nucleic acid-based bioTPD and others have also emerged and undergone significant advancement in recent years, demonstrating unique and promising activities beyond those of conventional small-molecule TPD.
    Trim-Away is an antibody-based bioTPD technology developed in 2017 that exploits commercially-available antibodies and TRIM21 for rapid protein disruption (Fig. 3 A) [ 16 ]. The endogenous level of TRIM21 is sufficient for protein degradation in several cell types, such as primary cells.
    By harnessing the cell’s disposal system, TPD represents a promising therapeutic modality that allows access to most proteins of choice, requiring only a target binder (also called protein degrader) to carry out its intended role.
  8. Frontiers | Identification and characterization of two closely related ...

  9. Beyond canonical PROTAC: biological targeted protein …

  10. The promise of targeted protein degradation approaches