- Embryonic carcinoma cell lineLearn more:✕This summary was generated using AI based on multiple online sources. To view the original source information, use the "Learn more" links.P19 cells is an embryonic carcinoma cell line derived from an embryo-derived teratocarcinoma in mice. The cell line is pluripotent and can differentiate into cell types of all three germ layers.en.wikipedia.org/wiki/P19_cellP19 cells are a type of stem cell that have become widely used in hematology and oncology research. These cells are derived from the embryonic carcinoma P19 tumor cell line, which was first developed in the 1980s.openaccesspub.org/hematology-and-oncology-res…
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See all on WikipediaP19 cells is an embryonic carcinoma cell line derived from an embryo-derived teratocarcinoma in mice. The cell line is pluripotent and can differentiate into cell types of all three germ layers. Also, it is the most characterized embryonic carcinoma (EC) cell line that can be induced into cardiac muscle cells and … See more
Cancer cells in humans may result in the patient's death if the aggressive cancer cell grows and metastasizes. However, researchers utilize … See more
P19 cells can be maintained in exponential growth because of a stable chromosomal composition. Because embryonal carcinoma can … See more
Treatment of undifferentiated P19 cells with retinoic acid can specifically induce them into neuronal cells. Using doses between 1 μM to 3 μM of RA can generate neurons as the most abundant cell type. Neurons under this treatment reached the highest populations … See more
Same as retinoic acid, DMSO induced differentiation is not specific to P19 cells. It could also induce neuroblastoma cells, lung cancer cells and mouse ES cells. At concentration of … See more
P19 cells provide valuable formation of both neuronal cells and muscle cells in vitro. Since P19 cells are easy to maintain and culture compared to other embryonic stem cells, they are a convenient model to perform developmental studies in vitro. Techniques to … See more
• Vanderheyden, M; Defize, L (2003). "Twenty one years of P19 cells: What an embryonal carcinoma cell line taught us about cardiomyocyte differentiation" See more
Wikipedia text under CC-BY-SA license WEBMay 1, 2003 · P19 EC cells, isolated from an experimental embryo-derived teratocarcinoma in mice, are multipotent and can differentiate into cell types of all three germ layers.
- Author: Marcel A.G. van der Heyden, Libert H.K. Defize
- Estimated Reading Time: 10 mins
- Publish Year: 2003
WEBAbstract. P19 cells are a line of pluripotent embryonal carcinoma able to grow continuously in serum-supplemented media. The differentiation of these cells can be controlled by nontoxic drugs. Retinoic acid effectively induces the development of neurons, astroglia and microglia--cell types normally derived from the neuroectoderm.
- Author: M W McBurney
- Publish Year: 1993
WEBApr 27, 2019 · The P19 cell line derived from a mouse embryo-derived teratocarcinoma has the ability to differentiate into the three germ layers. In the presence of retinoic acid (RA), the suspension cultured P19 cell line is induced to differentiate into neurons.
WEBP19 cells have been proposed to serve as an in vitro neuronal differentiation model for studying mAChR subtypes in a proper neuronal context, as differentiated P19 neurons express high concentrations of …
WEBJul 20, 2018 · P19-derived neural cells comprised of NES + neural progenitors (~ 46%), TUBB3 + immature neurons (~ 6%), MAP2 + mature neurons (~ 2%), and GFAP + astrocytes (~ 50%). A heterogeneous neuronal population consisting of glutamatergic, GABAergic, serotonergic, and dopaminergic neurons was generated.
WEBFeb 22, 2023 · Retinoic acid induces differentiation of P19 cells (UD-P19) to P19 neurons (P19N) that behave like cortical neurons and express characteristic neuronal genes such as NMDA receptor subunits. Here we report P19N exosome-mediated differentiation of UD-P19 to P19N.
WEBDec 24, 2022 · P19 cells, like other embryonal carcinoma stem cells, recruit the same mechanisms employed by normal embryonic cells to differentiate into neuron-like cells. Some valuable features of P19 cells are noteworthy: (i) these immortal cells permit access to unlimited amounts of material for analysis, (ii) they simply grow and remain in an ...
WEBHere, we propose that P19 cells can serve as a simple and convenient in vitro tool to investigate the molecular mechanisms of mesoderm formation and axial elongation morphogenesis. As demonstrated in this study, P19 cell aggregates can be effectively manipulated to examine the roles of specific genes in mesoderm development and axial …
WEBP19 embryonal carcinoma cells (EC-cells) provide a simple and robust culture system for studying neural development. Most protocols developed so far for directing neural differentiation of P19 cells depend on the use of culture medium supplemented with retinoic acid (RA) and serum, which has an undefined composition.
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