Mitochondrial fatty acid synthesis is an emergent central ... - Cell …
ويب20 دسمبر، 2023 · We do not understand the mechanism whereby mtFAS activity influences whole-cell metabolism and gene expression. Whole-cell metabolism and gene expression in turn influence cell function, stemness, and could have implications for whole body metabolism. How mtFAS functions change in specific cell types has limited …
Ketogenic diet promotes tumor ferroptosis but induces …
ويب12 جون، 2023 · Cancer, at a cellular and organismal level, is at least in part a metabolic disease. Cancer cells have altered metabolism to accommodate nutrient demand and maintain growth and proliferation. For example, they …
Gut bacteria-driven homovanillic acid alleviates ... - Cell Press
ويب5 اپریل، 2024 · The study by Zhao et al. shows that administering intestinal B. longum, R. intestinalis, or the neurotransmitter, homovanillic acid, improved depressive symptoms in mice. This highlights the role of gut microbial metabolism in maintaining synaptic integrity and suggests potential treatment strategies for depression.
Cardiovascular-kidney-metabolic syndrome: A step toward ... - Cell …
ويب5 دسمبر، 2023 · Next Article Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses. In a recent Presidential Advisory report, the American Heart Association (AHA) defined cardiovascular-kidney-metabolic (CKM) syndrome as a spectrum of pathology associated with dysfunctional or excess adiposity and leading to adverse …
Mitochondrial isocitrate dehydrogenase impedes CAR T cell ... - Cell …
ويب2 جنوری، 2024 · Metabolic adaptation results in skewed differentiation with reduced anti-tumor function of T cells. Si et al. identify that IDH2 limits pentose phosphate pathway activity and cytosolic citrate availability to impede memory CAR T cell formation. Pharmacological IDH2 inhibition enhances metabolic fitness and efficacy of CAR T cells, particularly under …
Tyrosine catabolism enhances genotoxic chemotherapy by ... - Cell …
ويب26 اکتوبر، 2023 · To gain insight into the amino acid metabolism that may affect the response to genotoxic chemotherapeutics, we performed a customized RNAi screen in an EOC cell line, SKOV3, using a lentiviral short hairpin RNA (shRNA) library of amino acid metabolism-related genes ().In the primary screen, we transduced SKOV3 cells with the individual lentivirus …
CD36 maintains lipid homeostasis via selective uptake of ... - Cell …
ويب17 اکتوبر، 2023 · Terry et al. find that palmitoylation of CD36 functions as a sensor for lipid saturation, which promotes monounsaturated fatty-acid-specific uptake to prevent saturation-induced lipotoxicity. In vivo, loss of CD36 prevents high-fat-diet-driven metastasis in breast cancer mouse models, and a palmitoylation-deficient CD36 does not rescue this effect.
Canagliflozin impairs T cell effector function via metabolic ...
ويب24 مئی، 2023 · Jenkins et al. report that the SGLT2 inhibitor, canagliflozin, compromises human T cell effector function. Canagliflozin prevents T cell activation and proliferation by antagonizing TCR signaling, impairing the activity of c-Myc, leading to a failure to engage in metabolic rewiring. In vitro, canagliflozin impairs T cell function in patients with autoimmunity.
Neutrophils resist ferroptosis and promote breast cancer ... - Cell …
ويب3 اکتوبر، 2023 · Zhao et al. report the induction of Acod1 in tumor-infiltrating neutrophils (TINs) and its critical role in blunting ferroptosis and sustaining viability for TINs. Acod1 ablation abates TIN density, constrains breast cancer metastasis, bolsters antitumor T cell immunity, and boosts the the anti-metastasis efficacy of immune checkpoint blockade in mice.
Fructose sweetens the adipocyte-T cell alliance against tumors
ويب5 دسمبر، 2023 · Dietary fructose is implicated in tumorigenesis, but whether dietary fructose regulates antitumor immunity remains elusive. In this issue of Cell Metabolism, Zhang et al. show that dietary fructose promotes adipocyte-derived leptin production, which attenuates terminal exhaustion programming and boosts the effector function of CD8+ T cells for …