Immunometabolism in cancer: basic mechanisms and new …
ويب16 مئی، 2024 · The metabolism of tumor cells causes a large deficiency of nutritional substrates, including glucose and glutamine, in the TME, which results in abnormal metabolism and function of the immune cell ...
Advances in Cellular Metabolism and Regulation - MDPI
ويب15 مئی، 2024 · Cellular metabolism is tightly regulated by various factors, such as genetic, epigenetic, environmental, and hormonal cues. Dysregulation of cellular metabolism can lead to various diseases, such as cancer, diabetes, and neurodegeneration. Therefore, understanding the mechanisms and pathways of cellular metabolism and regulation is …
Understanding osteokine biology: Cell Metabolism
ويب7 مئی، 2024 · Understanding osteokine biology. Bone is an endocrine organ that participates in whole-body homeostasis. The biology of bone-derived osteokines, however, remains unclear. Liang et al. integrate experimental and computational methods to discover new osteokines, establish their cell of origin and target site, and study their role in aging and ...
Intermittent fasting influences immunity and metabolism - Cell …
ويب7 مئی، 2024 · Intermittent fasting (IF) modifies cell- and tissue-specific immunometabolic responses that dictate metabolic flexibility and inflammation during obesity and type 2 diabetes (T2D). Fasting forces periods of metabolic flexibility and necessitates increased use of different substrates. IF can lower metabolic inflammation and improve glucose metabolism without …
Targeting metabolic circuitry to supercharge CD8 - Cell Press
ويب7 مئی، 2024 · Tumors compromise T cell functionality through various mechanisms, including the induction of a nutrient-scarce microenvironment, leading to lipid accumulation and metabolic reprogramming. Hunt et al. elucidate acetyl-CoA carboxylase’s crucial role in regulating lipid metabolism in CD8+ T cells, uncovering a novel metabolic strategy to …
Metabolic regulator ERRγ governs gastric stem cell ... - Cell Press
ويب10 مئی، 2024 · Gastric parietal cell dysregulation or loss characterizes many gastrointestinal diseases. Adkins-Threats, Arimura, et al. morphologically and molecularly characterize regenerating parietal cells and use a mouse model of gastric injury to demonstrate the necessity of druggable transcriptional regulator ERRγ for the production and maintenance …
Issue: Cell - Cell Press
ويب23 مئی، 2024 · Alba Diz-Muñoz. Mechanobiology—the field studying how cells produce, sense, and respond to mechanical forces—is pivotal in the analysis of how cells and tissues take shape in development and disease. As we venture into the future of this field, pioneers share their insights, shaping the trajectory of future research and applications.
Most recent papers in the journal Cell Metabolism | Read by QxMD
ويب14 مئی، 2024 · We profiled Gpr75 expression and report that it is most abundant in the brain. Next, we generated the first single-cell-level analysis of Gpr75 and identified a subpopulation co-expressed with key appetite-regulating hypothalamic neurons... 38653246. April 18, 2024: Cell Metabolism. # 12.
Targeting metabolic circuitry to supercharge CD8+ T cell …
ويب7 مئی، 2024 · The study by Hunt et al. marks a significant advance in our understanding of CD8 + T cell metabolism within the TME. Looking forward, it will be intriguing to explore whether ACC2 compensates for ACC1’s absence, given its compensatory role in other cellular contexts such as hepatic tissue. 3 Additionally, the long-term sustainability of antitumor …
Metabolomics - Latest research and news | Nature
ويب4 days ago · Metabolomics refers to the systematic identification and quantification of the small molecule metabolic products (the metabolome) of a biological system (cell, tissue, organ, biological fluid, or ...
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