Mitochondrial fatty acid synthesis is an emergent central ... - Cell …
ওয়েব20 ডিসেম্বর, 2023 · We do not understand the mechanism whereby mtFAS activity influences whole-cell metabolism and gene expression. Whole-cell metabolism and gene expression in turn influence cell function, stemness, and could have implications for whole body metabolism. How mtFAS functions change in specific cell types has …
Metabolism collection: Cell Press
ওয়েব25 জুলাই, 2023 · Metabolism. Metabolism encompasses all the chemical reactions in living organisms that generate or consume energy. It is the most fundamental process of life for microbes, parasites, plants, and animals. Metabolism impacts on, or is impacted by, virtually every other cellular process in these organisms. Understanding the role of …
Cellular metabolism regulates the differentiation and function of …
ওয়েব2 এপ্রিল, 2024 · Fatty acid metabolism and memory CD8 + T cell longevity. One crucial aspect of our adaptive immune system is the establishment of immunological memory, which provides protection against repeated ...
Cell Metabolism | Vol 35, Issue 9, Pages 1491-1672 (5 September …
ওয়েব5 সেপ্টেম্বর, 2023 · Read the latest articles of Cell Metabolism at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature
Issue: Cell Metabolism
ওয়েব6 ফেব, 2024 · The Cell Metabolism editorial team; While the successes of modern medicine have significantly extended the human lifespan, the burden of chronic metabolic disease increasingly impacts the quality of life of almost two billion people worldwide. It is now imperative that we recognize metabolic disease as a pandemic and urgently …
CD36 maintains lipid homeostasis via selective uptake of ... - Cell …
ওয়েব17 অক্টোবর, 2023 · Terry et al. find that palmitoylation of CD36 functions as a sensor for lipid saturation, which promotes monounsaturated fatty-acid-specific uptake to prevent saturation-induced lipotoxicity. In vivo, loss of CD36 prevents high-fat-diet-driven metastasis in breast cancer mouse models, and a palmitoylation-deficient CD36 does …
Fructose sweetens the adipocyte-T cell alliance against tumors
ওয়েব5 ডিসেম্বর, 2023 · Dietary fructose is implicated in tumorigenesis, but whether dietary fructose regulates antitumor immunity remains elusive. In this issue of Cell Metabolism, Zhang et al. show that dietary fructose promotes adipocyte-derived leptin production, which attenuates terminal exhaustion programming and boosts the effector function of …
Glutarate regulates T cell metabolism and anti-tumour immunity
ওয়েব21 আগস্ট, 2023 · T cell metabolism is greatly altered by T cell activation; a major driver of this metabolic change is the hypoxia-inducible factor 1-alpha (HIF-1α) transcription factor.
GDF15 is a major determinant of ketogenic diet-induced ... - Cell …
ওয়েব5 ডিসেম্বর, 2023 · KD feeding induces mild elevation of circulating GDF15, which suppresses energy intake and reduces body fat mass. Using either Gdf15−/− or Gfral−/− mice, we show that the GDF15-GFRAL axis is crucial for the weight-lowering effects of KD. We also corroborate that KD-induced GDF15 derives from activation of hepatic …
Deciphering the metabolic heterogeneity of hematopoietic stem cells …
ওয়েব2 জানু, 2024 · The predicted metabolites covered glycolysis, citrate cycle, pentose phosphate pathway (PPP), pyruvate metabolism, amino acid biosynthesis, pyrimidine metabolism, etc. t-SNE visualization of metabolomics differences between stem and progenitor cell populations by SVM analysis showed that all hematopoietic cell …
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