Single-cell transcriptome analysis defines mesenchymal stromal cells …
वेब1 मार्च 2022 · We digested the dental pulp of incisors from 5-6-day-old mice to single-cell suspension and performed scRNA-seq. Based on the differential expression of key developmental genes, we defined 16 distinct cell clusters in the dental pulp of mouse incisors (Fig. 1 A and Fig. S1).The majority of the dental pulp cell population consisted …
Clinical Potential and Current Progress of Dental Pulp Stem Cells …
वेब6 मार्च 2019 · Dental pulp stem cells (DPSCs) were the first human dental stem cells isolated from the dental pulp of permanent teeth , and stem cells from the deciduous teeth of infants, termed SHED (stem cells from human exfoliated deciduous teeth) have also been isolated . Dental pulp is a connective tissue encapsulated in the mineralized tooth …
Human dental pulp stem cells: Applications in future regenerative ...
वेब6 जून 2015 · INTRODUCTION. Stem cells are unspecialized cells having a property of self renewal and further differentiate into various types of specialized cells[].Stem Cells are identified in a number of adult tissues including skin, adipose tissues[], peripheral blood[3,4], bone marrow, pancreas, intestine, brain, hair follicles, as well as in the dental pulp …
Single-Cell Transcriptomic Analysis of Dental Pulp and …
वेब20 नव॰ 2023 · Our results revealed 7 distinct clusters, with cluster 3 showing the highest potential for differentiation. Clusters 0 to 2 displayed features similar to fibroblasts. The trajectory route of the cell state transition from cluster 3 to clusters 0, 1, and 2 indicated the distinct nature of cell differentiation. ... Chen D, Park M, Kim S, Choi YJ, Moon SJ, Shin …
DLP printed hDPSC-loaded GelMA microsphere regenerates dental pulp …
वेबMonolayer cultured dental pulp cells cluster more closely together than non-cultured dental pulp cells, suggesting a lower heterogeneous population with relatively consistent clusters and similar cellular composition. We successfully fabricated hDPSC-loaded microspheres by layer-by-layer photocuring with a digital light processing (DLP) printer. …
Single-cell atlas of dental pulp stem cells exposed to the oral ...
वेब23 मई 2023 · We explored the response of human dental pulp stem cells (hDPSCs) to bacterial invasion and the mechanisms underlying the impact of residual bacteria on dental pulp regeneration. Methods: Single-cell sequencing was used to categorize the hDPSCs into clusters based on their response to P. gingivalis and E. faecalis .
Functional Dental Pulp Regeneration: Basic Research and Clinical ...
वेब20 अग॰ 2021 · Figure 2. Three key elements in pulp regeneration: dental stem cells, biomaterials, and growth factors. Dental stem cells can be used as effector cells because of their multidirectional differentiation potential, and they can secrete exosomes and cytokines to regulate other niche cells through paracrine effects.
Dental Pulp Stem Cells: Advances to Applications - PubMed
वेब13 फ़र॰ 2020 · Dental pulp stem cells (DPSCs) have a high capacity for differentiation and the ability to regenerate a dentin/pulp-like complex. Numerous studies have provided evidence of DPSCs' differentiation capacity, such as in neurogenesis, adipogenesis, osteogenesis, chondrogenesis, angiogenesis, and dentinogenesis. The molecular …
Cells | Free Full-Text | Mechanobiology of Dental Pulp Cells - MDPI
वेब21 फ़र॰ 2024 · The dental pulp is the inner part of the tooth responsible for properly functioning during its lifespan. Apart from the very big biological heterogeneity of dental cells, tooth microenvironments differ a lot in the context of mechanical properties—ranging from 5.5 kPa for dental pulp to around 100 GPa for dentin and enamel. This physical …
Functional Dental Pulp Regeneration: Basic Research and
वेब20 अग॰ 2021 · Since the successful isolation and characterisation of dental pulp stem cells (DPSCs) and other applicable dental mesenchymal stem cells, basic research and preclinical exploration of stem cell-mediated functional pulp regeneration via cell transplantation and cell homing have received considerably more attention. Some of this …